Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 InfectionArticle Published on 2022-10-142022-11-16 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Adequate approach cancers cardiovascular disease chronic disease Chronic diseases communicable disease complementary coronavirus COVID-19 CVD Diabetes Mellitus dietary dietary supplements effective fasting fatty acids feasible hallmark immunomodulatory Importance Inflammation Inflammatory Intermittent intermittent fasting Modification nutraceutical obesity outcome oxidative oxidative stress Patient Polyunsaturated Post-infection quercetin Randomized controlled trial regimen SARS-CoV-2 Selection severe coronavirus disease suggested systemic Therapies time-restricted eating Treatment variant Vitamin vitamins vitamins. was performed [DOI] 10.3390/nu14204299 PMC 바로가기
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled TrialArticle Published on 2022-09-162022-11-15 Journal: Nutrients [Category] SARS, 진단, [키워드] 25-hydroxyvitamin D 95% CI Acute respiratory infection adjusted hazard ratio antibody baseline blood sample BNT162b2 BNT162b2 Pfizer boost Breakthrough SARS-CoV-2 infection cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 Oxford–AstraZeneca circulating collected Concentration concentrations Controlled deficiency determine dose dried blood spot Effect Efficacy elevated Follow-up IFN-γ IgA IgG IgM influence interferon interferon gamma investigated mean difference neutralising antibody neutralising antibody titre of BNT162b2 offer participant Pfizer Protective randomised controlled randomised controlled trial reported response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly supernatant titre titres vaccination venous Vitamin Vitamin D Vitamin D status vitamin D supplement Vitamin D supplementation vitamin D. Whole blood [DOI] 10.3390/nu14183821 PMC 바로가기
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins vitamins. Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN SurveyResearch article Published on 2022-09-012022-10-05 Journal: Pharmacological research [Category] 바이오마커, [키워드] Administered ascorbic acid Borg Combination COVID-19 Critical Effect effort Endothelial dysfunction endothelial function Evidence favorable effect IMPROVE in both groups indicate L-Arginine long-COVID oxidative stress pathophysiology Patient receiving recent reduce Result significant difference significantly lower survey Symptom Symptoms Treatment treatment arm two groups typical symptom Vitamin Vitamin C [DOI] 10.1016/j.phrs.2022.106360 [Article Type] Research article
Effects of bioactive compounds from Pleurotus mushrooms on COVID-19 risk factors associated with the cardiovascular systemReview article Published on 2022-09-012022-10-05 Journal: Journal of integrative medicine [Category] 치료제, [키워드] Anti-inflammatory antioxidant Antiviral agents cardiovascular system component Compound Concentration coronavirus coronavirus disease COVID-19 COVID-19 severity disease Effect Food supplements fungi highlight immune health Infectious disease metabolism metabolites mushroom pharmacological agents Pleurotus protective mechanism reduction in risk factor SARS-CoV-2 severity significantly therapeutic therapeutic potential tissue Treatment Vitamin [DOI] 10.1016/j.joim.2022.07.002 [Article Type] Review article
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2In-silico 스크리닝 및 in-vitro assay는 SARS-CoV-2에 대한 Indomethacin의 항바이러스 효과를 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analysis analyzed anti-inflammatory drug Antiviral effect applied can be used caused cellular Comparative Compound compounds Computational drug coronavirus coronavirus disease COVID-19 CTD death Differential gene expression drug drug candidate drug candidates Drug repurposing epithelial cell epithelial cells Gene Expression Host host response human cell human cells human lung human lung epithelial cells humans in-silico In-vitro in-vitro assay indomethacin Infection investigated moderate molecules mRNA expression profile nonsteroidal anti-inflammatory drug Perspective Protein responsible SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread tested the SARS-CoV-2 therapeutic Toxicogenomics treat Treatment Vaccine Vero CCL-81 cell Vero CCL-81 cells viral infection Virtual screening virtual screening. Vitamin was performed [DOI] 10.1016/j.compbiomed.2022.105788 PMC 바로가기 [Article Type] Article
The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patientsReview article Published on 2022-08-012022-10-05 Journal: Clinical Nutrition Open Science [Category] 임상, 치료제, [키워드] cause Clinical outcome coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical deficiency demonstrated dietary supplement Effectiveness Evidence immune system immunomodulatory effects infections information innate immune response management Micronutrient micronutrients mitigate overactive oxalate Patient patient population patients with COVID-19 pharmacological physiological physiological effect Prevent Randomized controlled trials reduce reduction in respiratory SARS-CoV-2 severe COVID-19 Therapeutic approach Toxicity viral infection Vitamin Vitamin C Zinc Zn [DOI] 10.1016/j.nutos.2022.06.006 [Article Type] Review article
COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults폴란드의 두 가지 유행성 전염병의 COVID-19 심각도 및 사망률과 입원한 젊은 성인의 SARS-CoV-2 감염의 나쁜 결과 예측Article Published on 2022-07-312022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition Adults adults hospitalized albumin Alpha Alpha variant analyzed blood cell blood cell counts C-reactive protein calcium Characteristics Clinical characteristics Comorbidities COVID-19 COVID-19 severity creatine creatine kinase creatinine D-dimer debatable decrease disease severity Factors filtration rate global public health glomerular filtration rate had no hematocrit hemoglobin Hospitalization identify increase in intensive care intensive care unit treatment interleukin interleukin-6 investigated Laboratory Lactate lactate dehydrogenase Leukocytosis Logistic regression lung involvement lymphocyte lymphopenia mechanical ventilation Mortality Myoglobin neutrophil Neutrophil-to-lymphocyte ratio neutrophilia no increase non-survivor obesity outcome pandemic Patient peptide performed Poland Poor predictor predictors procalcitonin red blood cell Retrospective study risk of death SARS-CoV-2 SARS-CoV-2 variants second wave severe COVID-19 severity survivor Treatment troponin I urea variant Vitamin Vitamin D3 Wave with COVID-19 Young adults. [DOI] 10.3390/v14081700 PMC 바로가기 [Article Type] Article